Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heterogeneous Catalysis01:22

Heterogeneous Catalysis

Heterogeneous catalysis involves a catalyst in a different phase from the reactants. It is a process where the catalyst and the reactants are in distinct phases, typically solid and gas or liquid.Most heterogeneous catalysts are metals, metal oxides, or acids. The list includes transition metals like iron (Fe), cobalt (Co), nickel (Ni), palladium (Pd), platinum (Pt), chromium (Cr), manganese (Mn), tungsten (W), silver (Ag), and copper (Cu). These metals possess partially vacant d orbitals that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seasonal shellfish exploitation by Neanderthals 115,000 years ago.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Synthesis and crystal structures of five fluorinated diphenidine derivatives.

Acta crystallographica. Section E, Crystallographic communications·2025
Same author

Past and present bacterial communities in deglaciating northern latitude catchments reveal varied soil carbon sequestration potential.

The Science of the total environment·2025
Same author

Hyperpolarised [2-<sup>13</sup>C]-pyruvate by <sup>13</sup>C SABRE in an acetone/water mixture.

The Analyst·2024
Same author

Determination of the pK<sub>a</sub> Value of a Brønsted Acid by <sup>19</sup>F NMR Spectroscopy.

Magnetic resonance in chemistry : MRC·2024
Same author

<i>In silico</i> simulations of diffusion tensors and tortuosity in cells grown on 3D-printed scaffolds for tissue engineering.

RSC advances·2024

Related Experiment Video

Updated: Jun 26, 2026

Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

17.4K

Rapid SABRE Catalyst Scavenging Using Functionalized Silicas.

Thomas B R Robertson1,2, Leon J Clarke1, Ryan E Mewis1

  • 1Department of Natural Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, UK.

Molecules (Basel, Switzerland)
|January 21, 2022
PubMed
Summary
This summary is machine-generated.

This study demonstrates effective iridium removal from SABRE hyperpolarized samples using functionalized silica gel scavengers. This advancement paves the way for developing biocompatible hyperpolarized agents for in vivo applications.

Keywords:
NMRSABREcatalyst deactivationhyperpolarisationsolid-supported silicas

More Related Videos

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
09:37

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Published on: October 18, 2019

9.8K
Author Spotlight: Standardizing the Development of Amine-Based Silica Composites as CO2 Adsorbents for Direct Air Capture
08:00

Author Spotlight: Standardizing the Development of Amine-Based Silica Composites as CO2 Adsorbents for Direct Air Capture

Published on: September 29, 2023

2.7K

Related Experiment Videos

Last Updated: Jun 26, 2026

Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

17.4K
Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
09:37

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Published on: October 18, 2019

9.8K
Author Spotlight: Standardizing the Development of Amine-Based Silica Composites as CO2 Adsorbents for Direct Air Capture
08:00

Author Spotlight: Standardizing the Development of Amine-Based Silica Composites as CO2 Adsorbents for Direct Air Capture

Published on: September 29, 2023

2.7K

Area of Science:

  • Chemical Engineering
  • Materials Science
  • Biomedical Imaging

Background:

  • Signal amplification by reversible exchange (SABRE) is a promising NMR hyperpolarization technique.
  • Iridium catalysts used in SABRE are unsuitable for biomedical applications due to toxicity concerns.

Purpose of the Study:

  • To investigate the efficacy of metal scavengers in removing iridium catalyst residues from SABRE solutions.
  • To identify optimal scavenger properties for efficient iridium removal.

Main Methods:

  • Inductively coupled plasma-optical emission spectroscopy (ICP-OES) was used to quantify residual iridium.
  • Various functionalized silica gel scavengers with different functionalities, chain lengths, and support materials were tested.
  • The impact of scavenger quantity on iridium removal was evaluated.

Main Results:

  • Specific functionalized silica gels demonstrated high efficiency in removing iridium.
  • One optimized scavenger reduced iridium levels to below 1 ppm within 2 minutes.
  • Scavenger functionality, chain length, and support identity significantly influenced iridium removal efficiency.

Conclusions:

  • Metal scavengers, particularly functionalized silica gels, can effectively remove toxic iridium catalyst residues from SABRE samples.
  • This method enables the preparation of biocompatible hyperpolarized agents for potential in vivo use.
  • Combining this scavenging approach with techniques like CASH-SABRE could facilitate rapid production of hyperpolarized contrast agents.