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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

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Melatonin/Cyclodextrin Inclusion Complexes: A Review.

Aikaterini Sakellaropoulou¹, Angeliki Siamidi², Marilena Vlachou²

¹Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 15784 Athens, Greece.

Molecules (Basel, Switzerland)

|January 21, 2022

Summary

Melatonin (MLT) solubility and absorption are improved by cyclodextrin (CD) complexation. This review highlights key findings on MLT/CD complexes, showing enhanced drug uptake for therapeutic applications.

Keywords:

cyclodextrins inclusion complexes melatonin

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Area of Science:

Pharmacology
Drug Delivery Systems
Supramolecular Chemistry

Background:

Melatonin (MLT) is a hormone with diverse physiological roles, including sleep regulation and antioxidant effects.
MLT is implicated in various conditions such as seasonal affective disorder (SAD), neurological disorders, and cancers.
Poor water solubility of MLT limits its bioavailability and therapeutic efficacy.

Purpose of the Study:

To review and consolidate key findings on the complexation of melatonin with cyclodextrins (CDs).
To evaluate the impact of CD complexation on MLT's physicochemical properties and in vivo performance.

Main Methods:

Literature appraisal of studies investigating MLT/CD complexes.
Analysis of characterization techniques including NMR, FT-IR, XRD, and DCS.
Review of in vivo experimental data on MLT/CD complex uptake.

Main Results:

MLT forms predominantly 1:1 inclusion complexes with various CDs.
Complexation significantly enhances the aqueous solubility of melatonin.
Characterization techniques confirm the formation and interaction within MLT/CD complexes.
In vivo studies demonstrate increased MLT uptake when complexed with CDs.

Conclusions:

Cyclodextrin complexation is an effective strategy to improve melatonin's solubility and bioavailability.
MLT/CD complexes show promise for enhanced therapeutic delivery of melatonin.
Further research into MLT/CD complexes can optimize drug delivery for various medical conditions.