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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
208

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Related Experiment Video

Updated: Oct 6, 2025

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Advances in Twin-Screw Granulation.

Valérie Vanhoorne1, Ashish Kumar2

  • 1Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg, B-9000 Ghent, Belgium.

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Summary

Twin-screw granulation (TSG) offers a versatile method for both wet and dry granulation of diverse powders. This emerging technology enables precise control over particle properties for various applications.

Keywords:
continuous manufacturingpharmaceutical processingwet granulation

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Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Materials Science

Background:

  • Twin-screw granulation (TSG) is an advanced processing technique for powder agglomeration.
  • It accommodates a broad spectrum of powder characteristics, enabling both wet and dry granulation methods.

Discussion:

  • TSG provides enhanced control over granule size distribution and density.
  • The process is adaptable for various materials, including active pharmaceutical ingredients (APIs) and excipients.
  • Comparison with conventional granulation methods highlights TSG's efficiency and versatility.

Key Insights:

  • TSG facilitates the production of granules with tailored physical properties.
  • The technology allows for process optimization to achieve desired granule attributes.
  • Successful granulation of challenging powders demonstrates TSG's broad applicability.

Outlook:

  • Further research into TSG for novel material formulations is warranted.
  • Optimization of TSG parameters can lead to improved product performance.
  • Exploration of continuous manufacturing integration with TSG holds significant potential.