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Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application.

Bruna G Carvalho1, Bruno T Ceccato1, Mariano Michelon2

  • 1Department of Material and Bioprocess Engineering, School of Chemical Engineering, University of Campinas (UNICAMP), Campinas 13083-852, Brazil.

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Microfluidics enables efficient, scalable production of lipid nanostructures for drug delivery. This technology offers sustainable, cost-effective methods for creating diverse nanoscale and microscale lipid carriers.

Keywords:
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Area of Science:

  • Biotechnology
  • Materials Science
  • Nanotechnology

Background:

  • Microfluidics is a key technology for engineering lipid-based nanostructures.
  • Lipid nanostructures serve as crucial carriers for drugs and genetic materials.
  • Microfluidic processes offer sustainability and scalability for nanostructure production.

Purpose of the Study:

  • To review recent advances in microfluidic synthesis of lipid nanostructures (nanoparticles, liposomes, etc.).
  • To explore microfluidic methods for producing giant unilamellar vesicles.
  • To discuss microfluidic strategies for controlled payload release and cellular environment mimicry.

Main Methods:

  • Review of microfluidic synthesis techniques for various lipid nanostructures.
  • Analysis of microfluidic approaches for giant unilamellar vesicle production.
  • Examination of droplet-based microfluidics and microgels for controlled release.

Main Results:

  • Microfluidics facilitates the design of diverse lipid nano- and micro-structures.
  • Scalable and cost-effective production of lipid-based carriers is achievable.
  • Advanced microfluidic systems enable controlled release and mimicry of cellular environments.

Conclusions:

  • Microfluidics is a transformative technology for lipid nanostructure synthesis.
  • It enables precise control over size, composition, and functionality.
  • Future trends point towards novel nano/micro-scale designs and applications in drug delivery and screening.