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Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application
Bruna G Carvalho1, Bruno T Ceccato1, Mariano Michelon2
1Department of Material and Bioprocess Engineering, School of Chemical Engineering, University of Campinas (UNICAMP), Campinas 13083-852, Brazil.
Pharmaceutics
|January 21, 2022
Summary
Microfluidics enables efficient, scalable production of lipid nanostructures for drug delivery. This technology offers sustainable, cost-effective methods for creating diverse nanoscale and microscale lipid carriers.
Area of Science:
- Biotechnology
- Materials Science
- Nanotechnology
Background:
- Microfluidics is a key technology for engineering lipid-based nanostructures.
- Lipid nanostructures serve as crucial carriers for drugs and genetic materials.
- Microfluidic processes offer sustainability and scalability for nanostructure production.
Purpose of the Study:
- To review recent advances in microfluidic synthesis of lipid nanostructures (nanoparticles, liposomes, etc.).
- To explore microfluidic methods for producing giant unilamellar vesicles.
- To discuss microfluidic strategies for controlled payload release and cellular environment mimicry.
Main Methods:
- Review of microfluidic synthesis techniques for various lipid nanostructures.
- Analysis of microfluidic approaches for giant unilamellar vesicle production.
- Examination of droplet-based microfluidics and microgels for controlled release.
Main Results:
- Microfluidics facilitates the design of diverse lipid nano- and micro-structures.
- Scalable and cost-effective production of lipid-based carriers is achievable.
- Advanced microfluidic systems enable controlled release and mimicry of cellular environments.
Conclusions:
- Microfluidics is a transformative technology for lipid nanostructure synthesis.
- It enables precise control over size, composition, and functionality.
- Future trends point towards novel nano/micro-scale designs and applications in drug delivery and screening.
