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Post Column Derivatization Using Reaction Flow High Performance Liquid Chromatography Columns
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Stationary Phases for Green Liquid Chromatography
Mikołaj Dembek1, Szymon Bocian1
1Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin Str. 7, 87-100 Torun, Poland.
Materials (Basel, Switzerland)
|January 21, 2022
Summary
Green chemistry offers solutions for hazardous waste in industrial research. This review explores stationary phases for liquid chromatography using only water, reducing organic solvent waste.
Area of Science:
- Analytical Chemistry
- Green Chemistry
Background:
- Industrial research, particularly in pharmaceuticals, relies heavily on liquid chromatography.
- This technique generates significant hazardous organic waste, necessitating sustainable alternatives.
- Green chemistry principles provide a framework for developing environmentally benign processes.
Purpose of the Study:
- To review stationary phases suitable for liquid chromatography using pure water as the mobile phase.
- To explore the impact of elevated temperatures on chromatographic separations in aqueous conditions.
- To consolidate information on novel materials and methods for waste reduction in chromatography.
Main Methods:
- Literature review of scientific publications on aqueous chromatography.
- Analysis of stationary phase characteristics for water-based mobile phases.
- Investigation of chromatographic performance at various elevated temperatures.
Main Results:
- Identification of various stationary phases capable of performing separations in purely aqueous environments.
- Demonstration that elevated temperatures can enhance separation efficiency in water-based chromatography.
- Highlighting the potential of specific materials to facilitate waste reduction.
Conclusions:
- Performing liquid chromatography with pure water as the mobile phase is a viable green chemistry approach.
- Novel stationary phases and optimized temperature conditions are key to successful aqueous separations.
- This strategy significantly reduces hazardous organic waste in industrial and pharmaceutical research.
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