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Capsaicin and Its Effect on Exercise Performance, Fatigue and Inflammation after Exercise
Gaia Giuriato1,2, Massimo Venturelli1,3, Alexs Matias2
1Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Nutrients
|January 21, 2022
Summary
Capsaicin may reduce neuromuscular fatigue by affecting afferent signaling or muscle relaxation rates, potentially via SERCA pumps. This suggests a novel mechanism for capsaicin's anti-fatigue effects during exercise.
Area of Science:
- Exercise Physiology
- Neuroscience
- Biochemistry
Background:
- Capsaicin (CAP) activates the TRPV1 channel, potentially enhancing ATP production, vascular function, and exercise performance.
- The precise mechanisms behind capsaicin's ergogenic and fatigue-resistance effects remain unclear.
Purpose of the Study:
- To investigate the anti-fatigue effects of capsaicin during cycling exercise.
- To explore the underlying mechanisms of capsaicin's impact on neuromuscular fatigue.
Main Methods:
- A double-blind, counterbalanced, crossover study involving 10 healthy males.
- Participants completed constant-load cycling time to exhaustion (TTE) trials after ingesting placebo or capsaicin.
- Neuromuscular fatigue was assessed using the interpolated twitch technique during maximal voluntary contractions (MVC).
Main Results:
- No significant differences in cardiorespiratory responses, RPE, or TTE were observed between placebo and capsaicin trials.
- Capsaicin significantly attenuated the reduction in potentiated twitch force post-exercise.
- Capsaicin tended to attenuate the decline in maximal relaxation rate, but did not affect MVC or voluntary muscle activation.
Conclusions:
- Capsaicin may attenuate neuromuscular fatigue by modulating afferent signaling or muscle relaxation kinetics.
- The sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) pumps are a potential mediator of these effects.
- Capsaicin's anti-fatigue effects might be linked to enhanced Ca2+ reuptake and faster muscle relaxation.
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