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Updated: Oct 6, 2025

Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
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Cloudy fluid, cloudy diagnosis.

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Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|January 21, 2022
PubMed
Summary

Cloudy peritoneal dialysis (PD) effluent, initially thought to be bacterial peritonitis, was diagnosed as high-grade B-cell lymphoma after persistent symptoms. This highlights a rare presentation of lymphoproliferative disorders in PD patients.

Keywords:
cloudy effluentlymphomaperitoneal dialysis

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Area of Science:

  • Nephrology
  • Oncology
  • Pathology

Background:

  • Peritoneal dialysis (PD) is a common treatment for end-stage renal disease.
  • Cloudy PD effluent is typically indicative of bacterial peritonitis, a serious complication requiring prompt antibiotic treatment.

Observation:

  • A patient undergoing PD presented with persistent cloudy effluent.
  • Initial diagnosis was bacterial peritonitis, and antibiotic therapy was initiated.
  • Despite treatment, the cloudy effluent persisted, prompting further investigation.

Findings:

  • Extensive analysis of the PD effluent revealed the presence of high-grade B-cell lymphoma.
  • The patient's cloudy effluent was a rare manifestation of a lymphoproliferative disorder, not infection.

Implications:

  • This case underscores the importance of considering non-infectious causes, such as lymphoma, in patients with persistent cloudy PD effluent.
  • Clinicians should include lymphoproliferative disorders in the differential diagnosis for such presentations.
  • Raising awareness of this rare association can lead to earlier diagnosis and improved patient outcomes in PD-associated malignancies.