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Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
Published on: November 22, 2024
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Is the AT-rich DNA of malaria parasites a drug target?
Michaela S Bulloch1, Stuart A Ralph1
1Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia.
Trends in Pharmacological Sciences
|January 21, 2022
Abstract:
A recent antimalarial screen by Alder and colleagues has uncovered a natural product, PDE-I2, with DNA-binding and schizonticidal activity against Plasmodium falciparum. Parasite specificity is likely conferred by the extremely high A+T content of the P. falciparum genome. We discuss here this character as a potential target for future drugs.
