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Updated: Oct 6, 2025
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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Th17 cells: from gut homeostasis to CNS pathogenesis
Jane H Buckner1, Oliver J Harrison2
1Center for Translational Immunology, Benaroya Research Institute, 1201 9th Ave, Seattle, WA 98101, USA; Department of Immunology, University of Washington, 750 Republican St., Seattle, WA 98108, USA.
Trends in Immunology
|January 21, 2022
Summary
T helper 17 (Th17) cells are vital for host defense but can cause inflammation. Intestinal Th17 cells act as a reservoir, potentially becoming pathogenic during severe inflammation.
Area of Science:
- Immunology
- Microbiology
- Inflammation research
Background:
- T helper 17 (Th17) cells are critical for host-microbe interactions.
- Dysregulated Th17 cell activity can lead to chronic inflammation and tissue damage.
- The heterogeneity and functional plasticity of Th17 cells in various inflammatory settings are not fully understood.
Purpose of the Study:
- To investigate the factors governing Th17 cell heterogeneity.
- To understand the role of intestinal Th17 cells in inflammatory responses.
- To determine if intestinal Th17 cells can serve as a source for pathogenic T cells.
Main Methods:
- Analysis of Th17 cell populations in the intestine.
- In vivo models of severe tissue inflammation.
- Characterization of Th17 cell differentiation and function.
Main Results:
- Intestinal Th17 cells exist as a distinct population.
- These intestinal Th17 cells can be mobilized and acquire pathogenic properties.
- Severe tissue inflammation can trigger the expansion and pathogenicity of Th17 cells from this reservoir.
Conclusions:
- Intestinal Th17 cells represent a reservoir that can be tapped during severe inflammation.
- Understanding this reservoir is key to controlling Th17-mediated pathology.
- This finding offers insights into managing inflammatory diseases driven by Th17 cells.
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