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EULAR points to consider when analysing and reporting comparative effectiveness research using observational data in

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Summary

New European Alliance of Associations for Rheumatology (EULAR) points to consider improve comparative effectiveness research in rheumatology. These guidelines address confounding and attrition bias in observational studies for more reliable real-world evidence.

Keywords:
epidemiologyhealth careoutcome assessmentpatient reported outcome measures

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Area of Science:

  • Rheumatology
  • Observational Research
  • Comparative Effectiveness

Background:

  • Comparative effectiveness research in rheumatology using observational data faces challenges.
  • Confounding and attrition bias are significant threats to treatment effectiveness comparisons over time.

Purpose of the Study:

  • To develop European Alliance of Associations for Rheumatology (EULAR) points to consider (PtC) for analyzing and reporting comparative effectiveness research.
  • Focus on improving the reliability of real-world studies in rheumatology.

Main Methods:

  • A three-step process adhering to EULAR Standard Operating Procedures was used.
  • Methods included a systematic review, multidisciplinary task force meetings, an online Delphi process, expert opinion, and a simulation study.
  • Feedback from a wider audience refined the final points to consider.

Main Results:

  • Three overarching principles and 10 PtC were formulated.
  • PtC address biases like attrition and confounding by indication.
  • Recommendations emphasize defining baselines, considering reasons for treatment cessation, and reporting missingness patterns.

Conclusions:

  • Clear recommendations for analysis and reporting are crucial for observational comparative effectiveness studies in rheumatology.
  • Adherence to these PtC enhances the trustworthiness of study results.
  • Reducing potential biases is essential for reliable real-world evidence in rheumatology.