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Flavonoid intakes inversely associate with COPD in smokers
Nicola P Bondonno1,2,3, Benjamin H Parmenter1,3, Frederik Dalgaard4
1Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
The European Respiratory Journal
|January 21, 2022
Summary
Higher dietary flavonoid intake is linked to a reduced risk of developing chronic obstructive pulmonary disease (COPD), particularly in smokers. While beneficial, this dietary approach should complement, not replace, smoking cessation efforts for optimal lung health.
Area of Science:
- Nutritional Epidemiology
- Respiratory Medicine
- Public Health
Background:
- Higher flavonoid consumption is associated with improved pulmonary function.
- The relationship between flavonoid intake and the risk of developing chronic obstructive pulmonary disease (COPD) remains largely unexplored.
Purpose of the Study:
- To investigate the association between total flavonoid intake, specific flavonoid subclasses, and major flavonoid compounds with the incidence of COPD.
- To analyze these associations in a large prospective cohort study in Denmark.
Main Methods:
- Prospective cohort study of 55,413 adults aged 50-65 without COPD at baseline.
- Flavonoid intake estimated using a food frequency questionnaire and the Phenol-Explorer database.
- Incident COPD cases identified through Danish nationwide registers; associations analyzed using Cox proportional hazards models.
Main Results:
- A total of 5,557 COPD cases were diagnosed over 23 years of follow-up.
- Highest versus lowest total flavonoid intake was associated with a 20% lower COPD risk (HR 0.80).
- Inverse associations were observed for all flavonoid subclasses and were significant in current and former smokers, but not never-smokers.
Conclusions:
- Dietary flavonoids may partially mitigate the risk of smoking-related COPD.
- While beneficial, flavonoid intake should be considered alongside smoking cessation as the primary strategy for COPD prevention.
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