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THE RELATIONSHIP BETWEEN ESR AND C-REACTIVE PROTEIN WITH VARIABLE LEVEL OF D-DIMER IN COVID-19

Husam Abdulkareem Hasan1, Nawfal Almubarak1, Murtadha A Jeber1

  • 1DEPARTMENT OF SURGERY, BASRAH MEDICAL COLLEGE, UNIVERSITY OF BASRAH, BASRAH, IRAQ.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|January 21, 2022
PubMed

Insights

In COVID-19 patients, elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels show a moderate positive correlation with D-Dimer. This suggests inflammatory markers can help predict D-Dimer increases in SARS-CoV-2 infection.

Area of Science:

  • Clinical Medicine
  • Infectious Diseases
  • Hematology

Background:

  • COVID-19, caused by SARS-CoV-2, is associated with a significant inflammatory response.
  • Elevated D-Dimer levels are common in severe COVID-19 cases, indicating a hypercoagulable state.
  • Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are key inflammatory markers.

Purpose of the Study:

  • To investigate the correlation between inflammatory markers (ESR, CRP) and D-Dimer levels in patients with COVID-19.
  • To assess the potential of ESR and CRP as predictors of D-Dimer elevation in SARS-CoV-2 infection.

Main Methods:

  • A study involving 74 patients (both genders) admitted to Al-Mawani teaching hospital between August and October 2020.
  • Collection of demographic data and measurement of inflammatory markers (ESR, CRP) and D-Dimer on the day of hospital admission.

Main Results:

  • A moderate positive correlation was observed between D-Dimer and ESR (r = 0.354, p = 0.002).
  • A moderate positive correlation was found between D-Dimer and CRP (r = 0.457, p < 0.05).
  • No significant relationship was found between demographic data and D-Dimer levels.

Conclusions:

  • In SARS-CoV-2 infection, ESR and CRP levels are moderately positively correlated with D-Dimer.
  • Increasing levels of ESR and CRP may help predict concurrent increases in D-Dimer.
  • These inflammatory markers can aid in predicting D-Dimer changes in COVID-19, provided other inflammatory conditions are excluded.
Abstract

Keywords:
COVID-19CRPD-DimerESR

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