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Updated: Oct 6, 2025
The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation
Published on: August 15, 2018
Infant mode of death in the neonatal intensive care unit: A systematic scoping review
Matthew Lin1, Rachel Deming2, Joanne Wolfe2
1Boston Children's Hospital, Division of Newborn Medicine, Boston, MA, USA. Matthew.lin@childrens.harvard.edu.
Objective:
To characterize literature that describes infant mode of death and to clarify how limitation of life-sustaining treatment (LST) is defined and rationalized.
Study Design:
Eligible studies were peer-reviewed, English-language, and included number of infant deaths by mode out of all infant deaths in the NICU and/or delivery room.
Result:
58 included studies were primarily published in the last two decades from North American and European centers. There was variation in rates of infant mode of death by study, with some showing an increase in deaths following limitation of LST over time. Limitation of LST was defined by the intervention withheld/withdrawn, the relationship between the two practices, and prior frameworks. Themes for limiting LST included diagnoses, low predicted survival and/or quality of life, futility, and suffering.
Conclusion:
Limitation of LST is a common infant mode of death, although rates, study definitions, and clinical rationale for this practice are variable.
