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The Association Between COVID-19 and Thyroxine Levels: A Meta-Analysis
Yiru Chen1, Xiuneng Li1, Yu Dai1
1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.
Frontiers in Endocrinology
|January 21, 2022
Summary
Thyroid hormone levels, including free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH), are linked to COVID-19 severity and mortality. Lower levels of FT3, FT4, and TSH may indicate increased mortality risk in COVID-19 patients.
Area of Science:
- Endocrinology
- Infectious Diseases
- Public Health
Background:
- Conflicting reports exist on the relationship between COVID-19 and thyroid hormones.
- Understanding this association is crucial for managing COVID-19 patients.
Purpose of the Study:
- To evaluate the effect of COVID-19 severity on thyroid hormones.
- To assess the impact of thyroid hormones on COVID-19 outcomes.
- To confirm the association between serum FT3, FT4, TSH levels and COVID-19 severity or mortality.
Main Methods:
- A meta-analysis was conducted.
- Systematic searches were performed on Cochrane Library, Embase, PubMed, and Web of Science.
- Keywords included thyroid hormones (T3, FT3, triiodothyronine, T4, FT4, thyroxine, TSH, thyrotropin) and COVID-19 (SARS-CoV-2).
Main Results:
- Twenty studies with 3609 patients were included.
- Thyroid hormone abnormalities were more frequent in severe COVID-19 cases.
- Serum FT3 and TSH levels were lower in severe COVID-19 patients; FT4 levels showed no significant difference.
- Abnormal thyroid hormones were associated with greater mortality.
Conclusions:
- Low FT3, FT4, and TSH levels may increase COVID-19 patient mortality.
- Increased COVID-19 severity correlates with decreased FT3, FT4, and TSH levels.
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