Reusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcohols
Zhuang Ma1, Bei Zhou1, Xinmin Li1
1Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a Rostock D-18059 Germany matthias.beller@catalysis.de jagadeesh.rajenahally@catalysis.de.
Abstract:
A general cobalt-catalyzed N-alkylation of amines with alcohols by borrowing hydrogen methodology to prepare different kinds of amines is reported. The optimal catalyst for this transformation is prepared by pyrolysis of a specific templated material, which is generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica, and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary, and tertiary amines including N-methylamines and selected drug molecules were conveniently prepared starting from inexpensive and easily accessible alcohols and amines or ammonia.
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