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Related Experiment Video

Updated: Oct 6, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

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Low-entropy lattices engineered through bridged DNA origami frames.

Di Gao1, Ningning Ma1, Xuehui Yan1

  • 1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, College of Engineering and Applied Sciences, Nanjing University Nanjing 210023 China ytian@nju.edu.cn minqianhao@nju.edu.cn jjzhu@nju.edu.cn.

Chemical Science
|January 21, 2022
PubMed
Summary

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Researchers engineered 3D low-entropy lattices using DNA origami frames and programmable DNA bridging. This method precisely controls nanoscale self-assembly for creating anisotropic metamaterials.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biotechnology

Background:

  • Self-assembly typically moves from order to disorder, an entropy-increasing process.
  • Achieving ordered, anisotropic structures at the nanoscale is challenging due to complex interactions.
  • Existing methods for anisotropic self-assembly are limited.

Purpose of the Study:

  • To engineer three-dimensional (3D) low-entropy lattices at the nucleotide level.
  • To demonstrate a precise method for controlling the spatial organization of anisotropic building blocks.
  • To create novel anisotropic metamaterials using DNA origami.

Main Methods:

  • Utilized modular DNA origami frames as building blocks.
  • Employed a programmable DNA bridging strategy for periodic arrangement of DNA domains.

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  • Integrated site-specific positioning of guest nanoparticles to control anisotropy.
  • Validated structural control using small-angle X-ray scattering and electron microscopy.

    • Main Results:

    • Successfully engineered 3D low-entropy lattices from DNA origami components.
    • Demonstrated precise control over the anisotropic arrangement of nanoscale components.
    • Validated the formation of ordered structures with specific spatial organization.
    • Showcased the integration of guest nanoparticles within the lattice structure.

    Conclusions:

    • The DNA origami-mediated crystallization method enables precise control over nanoscale self-assembly.
    • This approach facilitates the creation of anisotropic metamaterials with designed properties.
    • The method opens avenues for exploring advanced self-assembly platforms and functional nanomaterials.