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Updated: Oct 6, 2025

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
Published on: April 13, 2021
Reducing Kidney Discard With Artificial Intelligence Decision Support: the Need for a Transdisciplinary Systems
Richard Threlkeld1, Lirim Ashiku1, Casey Canfield1
1Engineering Management & Systems Engineering, Missouri University of Science & Technology, 223 Engineering Management 600 W 14th St, MO 65409 Rolla, USA.
Purpose Of Review:
A transdisciplinary systems approach to the design of an artificial intelligence (AI) decision support system can more effectively address the limitations of AI systems. By incorporating stakeholder input early in the process, the final product is more likely to improve decision-making and effectively reduce kidney discard.
Recent Findings:
Kidney discard is a complex problem that will require increased coordination between transplant stakeholders. An AI decision support system has significant potential, but there are challenges associated with overfitting, poor explainability, and inadequate trust. A transdisciplinary approach provides a holistic perspective that incorporates expertise from engineering, social science, and transplant healthcare. A systems approach leverages techniques for visualizing the system architecture to support solution design from multiple perspectives.
Summary:
Developing a systems-based approach to AI decision support involves engaging in a cycle of documenting the system architecture, identifying pain points, developing prototypes, and validating the system. Early efforts have focused on describing process issues to prioritize tasks that would benefit from AI support.
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Acute Kidney Injury V: Interprofessional Care
Kidney Transplant I: Introduction
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Chronic Kidney Disease III: Interprofessional Care
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Kidney Transplant III: Nursing Management

