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YAP/TAZ in Bone and Cartilage Biology
Mylène Zarka1,2, Eric Haÿ1,2, Martine Cohen-Solal1,2
1INSERM UMR 1132 BIOSCAR, Hôpital Lariboisière, Paris, France.
Frontiers in Cell and Developmental Biology
|January 21, 2022
Summary
The Hippo pathway
Area of Science:
- Biochemistry
- Cell Biology
- Developmental Biology
Background:
- YAP (Yes-associated protein) and TAZ (Transcriptional coactivator with PDZ-binding motif) are key regulators of organ growth.
- These proteins are influenced by mechanical and cytoskeletal cues within the cellular microenvironment.
- Mechanical signaling is crucial for bone tissue adaptation and remodeling.
Purpose of the Study:
- To review the regulation and function of YAP and TAZ.
- To provide new insights into the role of YAP/TAZ in bone biology.
- To explore the significance of YAP/TAZ in maintaining bone and cartilage homeostasis.
Main Methods:
- Literature review of YAP/TAZ regulation and function.
- Analysis of recent studies utilizing mice and cellular models.
- Synthesis of current understanding of YAP/TAZ in bone and cartilage cells.
Main Results:
- YAP/TAZ are implicated in bone biology beyond their developmental roles.
- Mechanical cues acting through YAP/TAZ are significant for bone homeostasis.
- Emerging models highlight crucial roles for YAP/TAZ in bone and cartilage cells.
Conclusions:
- YAP/TAZ play a significant role in bone and cartilage homeostasis.
- Understanding YAP/TAZ pathways offers new therapeutic targets for bone diseases.
- Further research in mice and cellular models is crucial for elucidating YAP/TAZ functions in bone.
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