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Updated: Oct 6, 2025
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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
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Targeting Epigenetic Mechanisms in Vascular Aging.
Zhongxiao Lin1,2, Qian Ding1, Xinzhi Li1
1State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macao SAR, China.
Frontiers in Cardiovascular Medicine
|January 21, 2022
Summary
Vascular aging, driven by lifestyle and genetics, contributes to serious diseases. Epigenetic changes are key drivers, offering potential targets for interventions to slow or reverse aging processes.
Area of Science:
- Cardiovascular Science
- Epigenetics
- Aging Research
Background:
- Vascular aging is a significant risk factor for cardiovascular diseases like diabetes, hypertension, atherosclerosis, and hyperlipidemia.
- Environmental factors, diseases, lack of exercise, and population demographics accelerate vascular aging.
- Rising hospitalization rates necessitate urgent interventions to combat vascular aging and its related diseases.
Purpose of the Study:
- To provide a comprehensive overview of epigenetic changes associated with vascular aging.
- To explore the molecular mechanisms underlying epigenetic deregulation in vascular aging.
- To discuss strategies for reversing epigenetic changes and future research directions.
Main Methods:
- Review of recent omics approaches to study vascular aging mechanisms.
- Analysis of epigenetic modifications including DNA methylation, histone modifications, and non-coding RNAs.
- Examination of the correlation between epigenetic alterations and vascular aging.
Main Results:
- Epigenetics, including DNA methylation, histone modifications, and non-coding RNAs, is a hallmark of vascular aging.
- Deregulation of epigenetic mechanisms leads to aberrant transcription and altered cellular signaling.
- Evidence strongly supports a correlation between epigenetic changes and the progression of vascular aging.
Conclusions:
- Epigenetic modifications play a crucial role in vascular aging.
- Understanding these epigenetic mechanisms offers potential therapeutic targets for slowing or reversing vascular aging.
- Further research into reversing epigenetic changes is essential for developing effective interventions.
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