Geroscience: the need to address some issues

Area of Science:

• Geroscience, a multidisciplinary field focused on aging.

Background:

• The geroscience hypothesis proposes delaying aging to prevent age-related diseases.
• This approach contrasts with individually treating each disease.
• Current challenges include over-enthusiasm and the direct translation of animal model findings to humans.

Purpose of the Study:

• To critically examine the geroscience hypothesis and its current limitations.
• To highlight the need for a comprehensive understanding of human aging.
• To advocate for a holistic approach that integrates social and behavioral factors.

Main Methods:

• Literature review and critical analysis of the geroscience field.
• Identification and discussion of key challenges and potential pitfalls.
• Argumentation for a more inclusive and less reductionist research paradigm.

Main Results:

• Geroscience faces challenges in translating animal findings to humans.
• The distinction between delaying aging, suppressing aging, and extending healthspan remains unclear.
• A risk of scientism and over-enthusiasm exists within the field.

Conclusions:

• Geroscience holds promise but requires careful consideration of its limitations.
• The field should avoid reductionist approaches and incorporate complex social and behavioral aspects of human aging.
• Addressing these issues is crucial for the responsible development of geroscience.