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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Lymphoblastic Lymphoma: a Concise Review
Tamara Intermesoli1, Alessandra Weber1, Matteo Leoncin2
1Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale (ASST), Ospedale Papa Giovanni XXIII, 24127, Bergamo, Italy.
Current Oncology Reports
|January 21, 2022
Summary
Lymphoblastic lymphoma (LBL), a rare aggressive cancer, is treatable with chemotherapy, achieving high cure rates. Advances in diagnostics and precision medicine aim to improve outcomes for the 25-30% of adults who relapse.
Area of Science:
- Hematology
- Oncology
- Internal Medicine
Background:
- Lymphoblastic lymphoma (LBL) is a rare, aggressive non-Hodgkin lymphoma.
- LBL is clinically and pathologically similar to acute lymphoblastic leukemia (ALL).
Purpose of the Study:
- To review advancements in diagnostics, staging, treatment, and response assessment for LBL.
- To highlight key features and treatment outcomes for T-LBL versus B-LBL.
Main Methods:
- Review of recent literature on LBL diagnostics and treatment.
- Analysis of diagnostic modalities including PET scans and genetic risk classifications.
- Evaluation of treatment strategies and response assessment.
Main Results:
- T-LBL, more common than B-LBL, often presents with mediastinal mass and effusions.
- LBL shows high sensitivity to ALL-type chemotherapy, with cure rates around 70% in adults and higher in children.
- Advanced diagnostics like PET and MRD assays aid in detecting disease and predicting outcomes.
- Stem cell transplantation is beneficial for high-risk or relapsed cases.
Conclusions:
- LBL is a curable malignancy for most patients, but 25-30% of adults face resistance or relapse.
- Early identification of refractory/relapsed cases is crucial.
- Precision medicine approaches with targeted agents are essential for improving outcomes in resistant disease.
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