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Magnesium in renal fibrosis.
Mengtuan Long1, Xiaoyu Zhu1, Xuejiao Wei1
1Department of Nephrology, The First Hospital of Jilin University, 1 Xinmin Street, Chaoyang District, Changchun, 130021, Jilin, People's Republic of China.
International Urology and Nephrology
|January 21, 2022
Summary
Magnesium (Mg2+) shows promise in preventing kidney disease progression by reducing inflammation and oxidative stress. This review explores magnesium
Area of Science:
- Nephrology
- Biochemistry
- Pathology
Background:
- Renal fibrosis (RF) is a key characteristic of chronic kidney disease (CKD).
- Inflammation and oxidative stress are prevalent in all stages of CKD.
- Developing strategies to prevent RF progression to end-stage renal disease (ESRD) is crucial for CKD treatment.
Purpose of the Study:
- To review existing evidence on the effects of magnesium (Mg2+) in renal fibrosis.
- To examine the potential mechanisms by which magnesium may delay the progression of RF.
Main Methods:
- Systematic literature search conducted on PubMed, Web of Science, and EMBASE.
- Focus on articles investigating the relationship between magnesium and fibrosis, specifically renal fibrosis.
Main Results:
- Mg2+ demonstrates anti-inflammatory effects by inhibiting inflammatory cell differentiation and reducing cytokine production.
- Mg2+ mitigates oxidative stress by decreasing reactive oxygen species (ROS) production.
- Mg2+ regulates apoptosis, protects renal tubular function, potentially influences TRPM6/7 channels, and promotes klotho secretion, thereby improving RF.
Conclusions:
- Magnesium (Mg2+) may serve as a therapeutic agent to prevent RF progression and delay CKD.
- Mechanisms include reducing renal inflammation and oxidative stress.
- Modulation of fibrosis-related signaling pathways and cytokines by Mg2+ contributes to its protective effects.
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