Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering programmable tumor microenvironment interactions through single-cell bioprinting of spatially defined cell microarrays.

Biofabrication·2026
Same author

Strategies for Craniofacial Tissue Engineering: Innovations for Scalable Bone Regeneration.

Plastic and aesthetic research·2025
Same author

Engineering neuronal networks in granular microgels to innervate bioprinted cancer organoids on-a-chip.

Lab on a chip·2025
Same author

Engineering models of head and neck and oral cancers on-a-chip.

Biomicrofluidics·2024
Same author

Multiplex Single-Cell Bioprinting for Engineering of Heterogeneous Tissue Constructs with Subcellular Spatial Resolution.

bioRxiv : the preprint server for biology·2024
Same author

High-Throughput Bioprinting of Geometrically-Controlled Pre-Vascularized Injectable Microgels for Accelerated Tissue Regeneration.

Advanced healthcare materials·2023

Related Experiment Video

Updated: Oct 6, 2025

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

16.9K

Bioprinting of Complex Multicellular Organs with Advanced Functionality-Recent Progress and Challenges Ahead.

Luiz E Bertassoni1,2,3,4

  • 1Division of Biomaterials and Biomechanics, School of Dentistry, Oregon Health and Science University, Portland, OR, 97201, USA.

Advanced Materials (Deerfield Beach, Fla.)
|January 21, 2022
PubMed
Summary

Bioprinting is advancing the creation of functional organs in the lab, moving beyond simple tissues to complex 3D structures. This review maps progress and highlights challenges in engineering functional, lab-grown organs for transplantation.

Keywords:
3D printingbioprintingorgan engineeringorganoidsvasculature

More Related Videos

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

10.2K
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

16.0K

Related Experiment Videos

Last Updated: Oct 6, 2025

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

16.9K
Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

10.2K
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

16.0K

Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Bioprinting offers a promising alternative to organ transplantation by enabling in-lab fabrication of functional organs.
  • Recent advancements have significantly improved the complexity and biological functionality of 3D multicellular constructs.

Purpose of the Study:

  • To review key milestones in bioprinting that have led to advanced tissue constructs.
  • To identify critical material, engineering, and biological challenges in organ fabrication.
  • To discuss the limitations of current bioprinting methods in replicating native organ complexity.

Main Methods:

  • Review of recent scientific literature and technological advancements in bioprinting.
  • Analysis of challenges in replicating multicellular organization and nanoscale extracellular environments.
  • Evaluation of existing bioprinting techniques and their suitability for complex organ engineering.

Main Results:

  • Significant progress has been made in creating bioprinted tissues with enhanced biological and architectural functionality.
  • Replicating the heterotypic organization and nanoscale precision of native organs remains a major challenge.
  • Existing bioprinting methods have limitations in overcoming barriers to complex organ fabrication.

Conclusions:

  • The field of bioprinting for functional organ manufacturing has seen unprecedented advances.
  • Addressing material, engineering, and biological challenges is crucial for future progress.
  • This review provides a roadmap for current progress and future research directions in bioprinting functional organs.