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Related Concept Videos

Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

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Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
132
Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

152
Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
152
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

1.1K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.1K
Dysrhythmias I: Introduction01:15

Dysrhythmias I: Introduction

183
Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
183
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

80
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
80
Pulse rhythm01:30

Pulse rhythm

973
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
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Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice
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Personalized approach in arrhythmology by genetic-based data: a case report.

Anastasia Victorovna Blokhina1, Alexandra Igorevna Ershova1, Elena Vitalievna Zyatenkova1

  • 1National Medical Research Center for Therapy & Preventive Medicine, Petroverigsky lane, 10/3, Moscow, 101990, Russia.

Personalized Medicine
|January 21, 2022
PubMed
Summary

Genetic testing identified a rare combination of inherited heart rhythm disorders in a young patient. This highlights its crucial role in personalized medicine for diagnosis and treatment of inherited channelopathies.

Keywords:
Brugada syndromeSCN5Aarrhythmologylong QT syndromemolecular genetic testingp.E1784Kpersonalized medicine

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Area of Science:

  • Cardiovascular Genetics
  • Clinical Diagnostics
  • Personalized Medicine

Background:

  • Inherited channelopathies, such as inherited arrhythmic syndromes, pose significant diagnostic and therapeutic challenges.
  • Molecular genetic testing offers insights into disease mechanisms and risk stratification.

Observation:

  • A young patient presented with a paradoxical combination of two distinct inherited arrhythmic syndromes.
  • This complex presentation necessitated a comprehensive diagnostic approach.

Findings:

  • Genetic testing was instrumental in accurately diagnosing the co-existing inherited channelopathies.
  • The results guided tailored treatment strategies and risk assessment for the patient.

Implications:

  • Integrating genetic testing into clinical practice enables a personalized medicine approach for inherited channelopathies.
  • This case underscores the value of genetic diagnostics in managing complex inherited cardiac conditions and preventing complications.