Ptercresions A-C: three new terpenes with hepatoprotective activity from Pteris cretica L

Three new terpenes were isolated from Pteris cretica L., namely ptercresions A (1), B (2) and C (3), together with two known terpenes and one terpene glycoside respectively identified as callisalignene D (4), berberiside A (5), creoside I (6). The structures of isolates were determined by HR-ESI-MS, ECD, NMR and acid hydrolysate analysis. The in vitro hepatoprotective activities of compounds 1-6 were studied against paracetamol-induced L-02 hepatocyte injury. The results revealed that compounds 2-4 showed moderate anti hepatocyte injury activity.