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Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Niosomal formulation for antibacterial applications.

Mehrnoush Mehrarya¹, Behnaz Gharehchelou¹, Samin Haghighi Poodeh¹

¹Protein Research Centre, Shahid Beheshti University, Tehran, Iran.

Journal of Drug Targeting

|January 21, 2022

Summary

Niosome nanoparticles offer a promising approach to deliver antibiotics directly to infection sites, minimizing damage to the body and enhancing treatment effectiveness for bacterial infections.

Keywords:

Niosome antibacterial bone implants dental implants local infection ocular drug delivery orthopaedic

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Published on: May 4, 2018

Area of Science:

Nanotechnology
Pharmaceutical Sciences
Infectious Diseases

Background:

Bacterial infections necessitate antibiotic treatment, which can cause systemic toxicity and disrupt beneficial microflora.
Targeted drug delivery systems are crucial to minimize antibiotic side effects and maximize therapeutic efficacy.
Niosomes, non-ionic surfactant-based nanoparticles, are emerging as advanced carriers for drug and antibiotic delivery.

Purpose of the Study:

To elucidate the molecular structure and physicochemical properties of niosomes.
To detail niosome manufacturing methodologies.
To review niosome applications in antibiotic delivery and their clinical effectiveness against bacterial infections.

Main Methods:

Literature review focusing on niosome formulation, characterization, and drug release mechanisms.
Analysis of studies investigating niosomes as carriers for antibiotic delivery.
Evaluation of clinical data on niosome efficacy in treating bacterial infections.

Main Results:

Niosomes demonstrate favorable characteristics for targeted drug delivery, reducing toxicity and enhancing accumulation at infection sites.
Niosomes have shown efficacy in local infections, ocular drug delivery, and implant coatings.
The review covers niosome manufacturing, drug release kinetics, and their potential in combating bacterial infections.

Conclusions:

Niosomes represent a significant advancement in drug delivery systems for antibiotics.
Targeted delivery via niosomes can mitigate the adverse effects of conventional antibiotic treatments.
Further research and clinical application of niosomes hold promise for improved management of bacterial infections.