Related Experiment Video

Updated: Oct 6, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.3K

Niosomal formulation for antibacterial applications

Mehrnoush Mehrarya1, Behnaz Gharehchelou1, Samin Haghighi Poodeh1

  • 1Protein Research Centre, Shahid Beheshti University, Tehran, Iran.

Journal of Drug Targeting
|January 21, 2022
PubMed

Insights

Niosome nanoparticles offer a promising approach to deliver antibiotics directly to infection sites, minimizing damage to the body and enhancing treatment effectiveness for bacterial infections.

Area of Science:

  • Nanotechnology
  • Pharmaceutical Sciences
  • Infectious Diseases

Background:

  • Bacterial infections necessitate antibiotic treatment, which can cause systemic toxicity and disrupt beneficial microflora.
  • Targeted drug delivery systems are crucial to minimize antibiotic side effects and maximize therapeutic efficacy.
  • Niosomes, non-ionic surfactant-based nanoparticles, are emerging as advanced carriers for drug and antibiotic delivery.

Purpose of the Study:

  • To elucidate the molecular structure and physicochemical properties of niosomes.
  • To detail niosome manufacturing methodologies.
  • To review niosome applications in antibiotic delivery and their clinical effectiveness against bacterial infections.

Main Methods:

  • Literature review focusing on niosome formulation, characterization, and drug release mechanisms.
  • Analysis of studies investigating niosomes as carriers for antibiotic delivery.
  • Evaluation of clinical data on niosome efficacy in treating bacterial infections.

Main Results:

  • Niosomes demonstrate favorable characteristics for targeted drug delivery, reducing toxicity and enhancing accumulation at infection sites.
  • Niosomes have shown efficacy in local infections, ocular drug delivery, and implant coatings.
  • The review covers niosome manufacturing, drug release kinetics, and their potential in combating bacterial infections.

Conclusions:

  • Niosomes represent a significant advancement in drug delivery systems for antibiotics.
  • Targeted delivery via niosomes can mitigate the adverse effects of conventional antibiotic treatments.
  • Further research and clinical application of niosomes hold promise for improved management of bacterial infections.
Keywords:
Niosomeantibacterialbone implantsdental implantslocal infectionocular drug deliveryorthopaedic

More Related Videos

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

2.1K
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

12.6K

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
4
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
5.0K
Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.6K
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.1K