Related Experiment Video

Updated: Oct 6, 2025

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
12:43

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

12.4K

p38 activation and viral infection

Luyao Wang1, Zhiqiang Xia1, Wei Tang1

  • 1State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan430072, Hubei, China.

Expert Reviews in Molecular Medicine
|January 21, 2022
PubMed

Insights

Viruses hijack host cell machinery. This review explores how the p38 MAPK pathway is activated during viral infections and its impact on virus replication, suggesting p38 as a potential antiviral target.

Area of Science:

  • Virology
  • Cellular Biology
  • Molecular Biology

Background:

  • Viruses depend on host cell metabolism and energy systems for replication.
  • Viral infections cause significant cellular damage and disease, with limited therapeutic options.
  • The p38 MAPK signaling pathway is implicated in various viral infections, acting as a crucial host factor.

Purpose of the Study:

  • To review the signaling pathways of p38 activation.
  • To summarize how diverse viruses induce p38 phosphorylation.
  • To elucidate the role of p38 activation in viral replication and its potential as an antiviral target.

Main Methods:

  • Literature review of signaling pathways.
  • Analysis of viral induction of p38 phosphorylation.
  • Synthesis of data on p38 activation and viral infections.

Main Results:

  • p38 MAPK pathway activation is a common host response to viral infections.
  • Different viruses utilize distinct mechanisms to trigger p38 phosphorylation.
  • p38 activation has a variable effect on viral replication, sometimes promoting and sometimes inhibiting it.

Conclusions:

  • Understanding p38 activation mechanisms in viral infections is critical for developing novel antiviral strategies.
  • Targeting the p38 pathway presents a promising therapeutic avenue for combating viral diseases.
  • This review consolidates current knowledge on p38's role in virology, highlighting its potential for drug development.
Keywords:
Activationantiviral targetinfectionp38 MAPKvirus

More Related Videos

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

10.6K
A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF311:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

12.1K

Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.0K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
12.9K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
6.4K