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Related Concept Videos

Lethal Alleles02:41

Lethal Alleles

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Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
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Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Pedigree Analysis01:35

Pedigree Analysis

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Overview
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Epistasis01:39

Epistasis

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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

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Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
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Cloning of Dolly the Sheep01:08

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The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
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Related Experiment Video

Updated: Oct 5, 2025

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation
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Lethal foal syndrome affects thoroughbreds too.

Georgina Mills

    The Veterinary Record
    |January 21, 2022
    PubMed
    Summary

    Fragile foal syndrome, a genetic disorder, has been confirmed in a non-warmblood horse for the first time. This discovery expands our understanding of the condition

    Area of Science:

    • Equine genetics
    • Animal health
    • Veterinary medicine

    Background:

    • Fragile foal syndrome (FFS) is a severe genetic disorder affecting horses.
    • Previously, FFS was primarily documented in Warmblood breeds.
    • This report details the first confirmed case in a non-Warmblood equine.

    Discussion:

    • The identification of FFS in a new equine population suggests broader genetic implications.
    • This finding necessitates a re-evaluation of diagnostic approaches and genetic screening protocols.
    • Understanding the genetic basis of FFS in diverse breeds is crucial for effective management.

    Key Insights:

    • Confirmed first case of fragile foal syndrome in a non-Warmblood horse.
    • Challenges the previous breed-specific understanding of FFS.

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  • Highlights the importance of genetic diversity in equine health research.

    • Outlook:

    • Further research is needed to determine the prevalence of FFS in non-Warmblood populations.
    • Potential development of new genetic tests applicable across various horse breeds.
    • Improved understanding may lead to better breeding strategies and reduced incidence of FFS.