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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
Spectrum of MRI Features of Mucin-producing Neoplasms in the Abdomen and Pelvis
Pei-Kang Wei1, Mamta Gupta1, Leo L Tsai1
1From the Departments of Radiology (P.K.W., L.L.T., K.S.L., M.P.S., A.S.S.B.) and Pathology (M.G.), Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215; Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.M.J.); and Department of Radiology, Mayo Clinic, Jacksonville, Fla (J.D.L.).
Abstract:
Mucin-producing neoplasms in the abdomen and pelvis are a distinct entity, separate from simple fluid-containing neoplasms and loculated fluid collections. Mucin is a thick gelatinous substance and-owing to its high water content-has imaging features that can be mistaken for those of simple fluid-containing neoplasms with multiple imaging modalities. However, mucin-producing neoplasms arise from specific organs in the abdomen and pelvis, with unique imaging appearances, knowledge of which is important to guide accurate diagnosis and management. With its large field of view and high soft-tissue resolution, MRI has advantages over other imaging modalities in characterizing these neoplasms. The authors focus on the spectrum of MRI features of such mucin-producing neoplasms and illustrate how-despite a varied organ origin-some of these neoplasms share similar MRI and histopathologic features, thereby helping narrow the differential diagnosis. One common finding in these tumors is that the presence of internal complexity and solid enhancing components increases as the degree of malignant transformation increases. Lack of internal complexity generally indicates benignity. These tumors have a varied range of prognosis; for example, a low-grade appendiceal mucinous neoplasm is indicative of a good prognosis, while a mucinous tumor of the rectum is known to manifest at an early age with aggressive behavior and poorer prognosis compared with its nonmucinous counterpart. Online supplemental material is available for this article. ©RSNA, 2022.
Insights
Mucin-producing neoplasms in the abdomen and pelvis have unique imaging features that can mimic simple fluid collections. MRI helps differentiate these tumors, with complexity indicating malignancy and lack of complexity suggesting benignity.
Area of Science:
- Gastroenterology
- Radiology
- Oncology
Background:
- Mucin-producing neoplasms present diagnostic challenges due to imaging similarities with simple fluid collections.
- Accurate differentiation is crucial for appropriate patient management and prognosis.
Purpose of the Study:
- To review the spectrum of MRI features of mucin-producing neoplasms in the abdomen and pelvis.
- To highlight shared MRI and histopathologic features across different organ origins to aid differential diagnosis.
Main Methods:
- Review of MRI characteristics of mucin-producing neoplasms.
- Correlation of imaging findings with histopathologic features and clinical outcomes.
Main Results:
- MRI is advantageous for characterizing mucin-producing neoplasms due to its high soft-tissue resolution and field of view.
- Internal complexity and solid enhancing components on MRI correlate with increased malignant transformation.
- Lack of internal complexity generally indicates a benign nature.
Conclusions:
- Understanding the MRI features of mucin-producing neoplasms is essential for accurate diagnosis and management.
- MRI findings, particularly internal complexity, can help narrow the differential diagnosis and predict prognosis.
- Prognosis varies significantly, from good for low-grade appendiceal mucinous neoplasms to poorer for aggressive rectal mucinous tumors.
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