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Coordination games in cancer.

Péter Bayer^1,2, Robert A Gatenby³, Patricia H McDonald⁴

¹Toulouse School of Economics, Toulouse, France.

|January 21, 2022

Summary

Coordination games offer new insights into cancer progression. Understanding these evolutionary games can reveal novel therapeutic strategies for cancer treatment.

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Area of Science:

Evolutionary biology
Cancer research
Game theory

Background:

Evolutionary games model cell interactions in cancer.
Coordination games are understudied in cancer research despite their potential.
Existing models often focus on Prisoner's Dilemma or public goods games.

Purpose of the Study:

To propose a model of cancer initiation and progression using evolutionary coordination games.
To identify conditions under which coordination games evolve between cancer cells.
To explore therapeutic strategies targeting cancer coordination games.

Main Methods:

Theoretical modeling of evolutionary coordination games.
Analysis of cancer cell interactions within a game theory framework.
Exploration of game-theoretic principles for therapeutic intervention.

Main Results:

Identified conditions for the evolution of coordination games in cancer.
Proposed specific aspects of cancer biology that can be modeled by coordination games.
Outlined potential therapeutic avenues based on exploiting coordination games.

Conclusions:

Coordination games provide a valuable, underutilized framework for understanding cancer.
This model offers new perspectives on cancer initiation, progression, and treatment.
Exploiting coordination games presents a promising direction for novel cancer therapies.