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Related Experiment Videos

Parity specific perinatal mortality. A longitudinal study based on sibships.

R Skjaerven1, L M Irgens, R T Lie

  • 1Medical Birth Registry of Norway.

Paediatric and Perinatal Epidemiology
|September 1, 1987
PubMed
Summary

Previous perinatal loss significantly increases the risk of future infant mortality, with recurrence risk being substantial. Overall improvements in perinatal care do not benefit all women equally.

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Area of Science:

  • Perinatal health
  • Reproductive epidemiology
  • Biostatistics

Background:

  • Perinatal mortality remains a significant concern in public health.
  • Understanding risk factors for recurrent perinatal loss is crucial for targeted interventions.
  • Previous studies have not fully accounted for the heterogeneity of risk within populations.

Purpose of the Study:

  • To analyze parity-specific perinatal mortality trends.
  • To identify the impact of previous perinatal loss on subsequent outcomes.
  • To investigate the influence of maternal age and birth year on perinatal mortality risks.

Main Methods:

  • Utilized the Medical Birth Registry of Norway for data from 1967-1981.
  • Employed linear logistic regression models.

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  • Controlled for maternal age, birth year, and survival of earlier births.

    • Main Results:

    • Risk of perinatal loss increased up to 6.0-fold after one prior loss and 17.0-fold after three prior losses.
    • Mortality reduction trends varied by parity and maternal age.
    • No consistent secular reduction in risk was observed for sibships with a first-born perinatal loss; some subgroups saw increased risk.
    • Maternal age effect on risk was significant for first births but diminished with higher parities after controlling for prior survival.

    Conclusions:

    • Heterogeneity of risk among women must be considered in perinatal loss studies.
    • Overall improvements in perinatal mortality do not uniformly apply to all women.
    • Increasingly, perinatal losses are non-random, with heightened recurrence risks indicating the need for personalized risk assessment.