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Pyoderma Gangrenosum Induced by BNT162b2 COVID-19 Vaccine in a Healthy Adult
Mazin Barry1, Abdulaziz AlRajhi1, Khaldoon Aljerian2
1Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Vaccines
|January 22, 2022
Summary
Pyoderma gangrenosum (PG) is a rare skin condition. This case study details the first reported instance of PG developing after the Pfizer-BioNTech COVID-19 vaccine (BNT162b2).
Area of Science:
- Dermatology
- Vaccinology
- Immunology
Background:
- Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis with unknown causes.
- COVID-19 vaccines, including mRNA vaccines like BNT162b2, can cause adverse skin reactions.
- PG associated with mRNA vaccines has not been previously documented.
Observation:
- A 27-year-old man developed skin lesions 24 hours post-Pfizer-BioNTech (BNT162b2) COVID-19 vaccination.
- A painful ulcerative lesion on his hand showed characteristic PG on biopsy.
- The lesion improved with immunosuppressive therapy.
Findings:
- This case study reports the first occurrence of PG following the BNT162b2 mRNA vaccine.
- Histopathological analysis confirmed pyoderma gangrenosum.
Implications:
- PG may be a rare adverse event associated with the BNT162b2 vaccine.
- Increased vigilance for skin manifestations post-mRNA vaccination is crucial.
- Ongoing monitoring is essential for identifying rare vaccine side effects.
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