Related Experiment Video

Updated: Oct 5, 2025

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

16.1K

Hepatitis C virus and kidney transplantation: Recent trends and paradigm shifts

Guy El Helou1, Colleen Jay2, Marina Nunez3

  • 1Department of Internal Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, FL 32608, United States of America.

Transplantation Reviews (Orlando, Fla.)
|January 22, 2022
PubMed

Insights

Direct-acting antivirals can now effectively treat Hepatitis C virus (HCV) infection, improving outcomes for kidney transplant patients. Research also explores transplanting kidneys from HCV-viremic donors to uninfected recipients.

Area of Science:

  • Nephrology and Transplant Immunology
  • Hepatology and Virology

Background:

  • Hepatitis C virus (HCV) infection significantly impairs patient and graft survival post-kidney transplantation.
  • Recent advancements in direct-acting antivirals (DAAs) offer effective HCV elimination.
  • Increased HCV prevalence in donors has led to a rise in HCV-viremic donor to uninfected recipient kidney transplants.

Purpose of the Study:

  • To review the current literature on HCV infection in kidney transplantation.
  • To discuss the epidemiology, clinical outcomes, and treatment of HCV in transplant recipients.
  • To examine the practice and ongoing debates surrounding transplantation from HCV-viremic donors to uninfected recipients.

Main Methods:

  • Comprehensive literature search on Hepatitis C virus and kidney transplantation.
  • Review of studies on HCV treatment efficacy with direct-acting antivirals.
  • Analysis of outcomes data for kidney transplantation involving HCV-viremic donors.

Main Results:

  • Direct-acting antivirals demonstrate effectiveness in treating HCV in kidney transplant recipients.
  • Transplantation of kidneys from HCV-viremic donors into uninfected recipients is an emerging practice.
  • Limited data suggest improved outcomes for treated HCV-infected kidney transplant patients.

Conclusions:

  • Effective HCV treatment with DAAs has transformed management in kidney transplant recipients.
  • Protocols for transplanting kidneys from HCV-viremic donors require further optimization and debate.
  • Additional research with longer follow-up is crucial to fully understand long-term outcomes.

Keywords:
Direct-acting antiviralsHCVHepatitis CKidney transplant

More Related Videos

Murine Kidney Transplant Technique08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

16.5K
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

8.0K

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
70
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
86
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
75
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
93
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
10
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
101