Related Experiment Video
Updated: Oct 5, 2025
08:18
Three-Dimensional Reconstruction of Orbital Fractures
Published on: May 16, 2025
352
Presenting features for developmental cysts of the orbit.
Caroline Wilde1, Kaveh Vahdani1, Caroline Thaung2
1Orbital Service, Moorfields Eye Hospital, London, EC1V 2PD, UK.
Eye (London, England)
|January 22, 2022
Summary
Orbital developmental cysts present varied clinical features, with dermoid and epidermoid types being most common. Conjunctival cysts are less inflamed and typically located medially.
Area of Science:
- Ophthalmology
- Pathology
- Surgical Science
Background:
- Orbital developmental cysts encompass a spectrum of lesions, ranging from common dermoid cysts to rare respiratory epithelial-lined cysts.
- Understanding their diverse clinical presentations and histological subtypes is crucial for accurate diagnosis and management.
Purpose of the Study:
- To evaluate the clinical features of developmental cysts of the orbit.
- To correlate cyst location and histological type with presenting symptoms and signs.
Main Methods:
- Retrospective study of 358 patients who underwent surgical excision of orbital cysts between 1992 and 2020.
- Analysis of patient demographics, presenting features, cyst location, and histological findings.
Main Results:
- The most common presenting features were peribulbar lumps, eyelid swelling, proptosis, pain, and reduced vision.
- Epidermoid, sebaceous, and keratinised dermoid cysts predominantly affected the superotemporal quadrant, while conjunctival cysts were typically medial.
- Histologically, keratinised epithelium with dermal structures was most frequent (63%), followed by non-keratinised epithelium with dermal structures (19%). Chronic inflammation was observed in 66% of cysts, with granuloma formation in 50%.
Conclusions:
- Orbital developmental cysts exhibit diverse clinical and histological characteristics.
- Conjunctival cysts are less inflamed and favor the superonasal quadrant, whereas deeper respiratory cysts may present later in life.
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