Related Experiment Video

Updated: Oct 5, 2025

Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function
11:47

Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function

Published on: January 22, 2017

10.7K

Exploring multifunctional antioxidants as potential agents for management of neurological disorders

Rakesh K Sindhu1, Prabhjot Kaur2, Parneet Kaur2

  • 1Chitkara College of Pharmacy, Chitkara University, Punjab, 140401, India. rakesh.sindhu@chitkara.edu.in.

Environmental Science and Pollution Research International
|January 22, 2022
PubMed

Insights

Antioxidants combat oxidative stress, a key factor in neurological diseases like Alzheimer's and Parkinson's. Tailored antioxidant therapies show promise for preventing and treating these complex brain disorders.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • Oxidative stress and free radicals are implicated in the pathogenesis of numerous human neurological diseases.
  • Understanding the complex biochemistry of oxidative pathobiology is crucial for effective therapeutic strategies.

Purpose of the Study:

  • To explore the potential of free radical scavengers (antioxidants) in preventing, delaying, or ameliorating neurological disorders.
  • To highlight the role of antioxidants in mitigating cellular damage associated with neurodegenerative diseases.

Main Methods:

  • Review of in vitro and animal model studies on antioxidant compounds in neurological disease.
  • Analysis of antioxidant mechanisms, including ROS scavenging, lipid peroxidation prevention, and mitochondrial protection.
  • Examination of specific antioxidant applications in Huntington's disease, Alzheimer's disease, and Parkinson's disease.

Main Results:

  • Antioxidants reduce cell damage, including mitochondrial dysfunction, DNA mutations, and lipid peroxidation.
  • Vitamin E scavenges reactive oxygen species (ROS) and prevents lipid peroxidation.
  • Creatine aids mitochondrial function in Parkinson's disease, while metal chelators prevent metal accumulation.

Conclusions:

  • The antioxidant defense system is a highly useful therapeutic approach for various neurological disorders.
  • Optimized antioxidant therapies, tailored to specific diseases, hold significant potential for neuroprotection.
Keywords:
AntioxidantsNeurodegenerative disordersROSSODVitamin E

More Related Videos

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.6K
Simultaneous Flow Cytometric Characterization of Multiple Cell Types Retrieved from Mouse Brain/Spinal Cord Through Different Homogenization Methods10:24

Simultaneous Flow Cytometric Characterization of Multiple Cell Types Retrieved from Mouse Brain/Spinal Cord Through Different Homogenization Methods

Published on: November 19, 2019

13.9K

Related Concept Videos

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
226
The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview
49.5K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
283
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
805
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.7K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.1K