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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Micropuncture closure following high density microarray patch application in healthy subjects.

Joakim Henricson^1,2, David A Muller³, S Ben Baker⁴

¹Department of Biomedical and Clinical Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)

|January 22, 2022

Summary

This summary is machine-generated.

High-density microarray patches (HD-MAP) effectively deliver vaccines and induce a safe inflammatory response. Skin barrier function fully recovers within 48 hours after HD-MAP application, ensuring safety and efficacy.

Keywords:

evaporimetry microneedles polarisation reflectance spectroscopy skin barrier integrity skin reactivity vaccination

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Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

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Published on: February 21, 2019

Area of Science:

Dermatology
Vaccinology
Biomaterials

Background:

High-density microarray patch (HD-MAP) technology offers a promising vaccination platform for global health.
HD-MAPs facilitate efficient vaccine delivery and stimulate innate immune responses.
The application must balance reactivity with rapid skin recovery.

Purpose of the Study:

To assess the safety and skin recovery profile of the HD-MAP vaccination system.
To evaluate the induction of local inflammatory responses and subsequent skin barrier restoration.

Main Methods:

1x1 cm HD-MAP patches with 5000 microprojections were applied to 12 healthy volunteers.
Skin barrier function was measured using transepidermal water loss (TEWL).
Skin reactivity was assessed via response to topical histamine challenge.

Main Results:

All HD-MAP application sites demonstrated restored skin barrier function by 48 hours.
Skin resistance to topical histamine challenge returned to baseline levels within 48 hours.
TEWL measurements confirmed the return of normal skin barrier function.

Conclusions:

HD-MAP application is safe, with complete skin barrier recovery within 48 hours.
The findings support previous observations on TEWL normalization and skin resistance recovery.
HD-MAPs are a viable vaccination platform with acceptable skin reactivity and recovery profiles.