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Updated: Oct 5, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase

BinQing Wei1, Kirk Robarge1, Sharada S Labadie1

  • 1Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Bioorganic & Medicinal Chemistry Letters
|January 22, 2022
PubMed

Keywords:
GlycolysisLactate dehydrogenaseStructure-based designTumor metabolismX-ray crystal structure

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