Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Where have dysplastic nevi led us?

M A Tucker1

  • 1Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892.

Princess Takamatsu Symposia
|January 1, 1987
PubMed
Summary

Researchers identified a single, highly penetrant, autosomal dominant gene linked to melanoma and unusual moles. This gene, primarily located on chromosome 1p, significantly increases melanoma risk in affected families.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia.

Genetics in medicine : official journal of the American College of Medical Genetics·2021
Same author

TET2 binds the androgen receptor and loss is associated with prostate cancer.

Oncogene·2016
Same author

A 20 Year Clinical and Laboratory Study of Familial B-Chronic Lymphocytic Leukemia in a Single Kindred.

Leukemia & lymphoma·2016
Same author

Revisiting the cost of carnivory in mammals.

Journal of evolutionary biology·2016
Same author

Reliability of 24-h void frequency as an index of hydration status when euhydrated and hypohydrated.

European journal of clinical nutrition·2016
Same author

Risk factors for second acute myeloid leukemia/myelodysplastic syndrome among survivors of non-Hodgkin lymphoma.

Leukemia·2015

Area of Science:

  • Genetics
  • Dermatology
  • Cancer Research

Background:

  • Cutaneous malignant melanoma is a significant health concern.
  • Familial melanoma cases often present with unusual moles (dysplastic nevi).
  • Dysplastic nevi are indicators of increased melanoma risk.

Purpose of the Study:

  • To investigate the genetic basis of familial melanoma and dysplastic nevi.
  • To identify the chromosomal location of the gene responsible for melanoma susceptibility.

Main Methods:

  • Clinical examination of melanoma-prone families (B. and K. families).
  • Morphological and distributional analysis of dysplastic nevi.
  • Formal genetic analyses, including linkage studies.

Main Results:

  • Dysplastic nevi and melanoma traits are linked to a single autosomal dominant gene.
  • Weak linkage identified with Rh on chromosome 1p.
  • Linkage excluded with several other chromosomal regions (e.g., 6p, 3q, 11p, 14q).

Conclusions:

  • A highly penetrant autosomal dominant gene on chromosome 1p is strongly associated with melanoma and dysplastic nevus susceptibility.
  • Further research is needed to pinpoint the specific gene and its product to understand melanoma etiology.

Related Experiment Videos