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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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Cardiac valve calcification is associated with mortality in hemodialysis patients: a retrospective cohort study

Jiuxu Bai1, Xiaoling Zhang2, Aihong Zhang1

  • 1Department of Blood Purification, General Hospital of Northern Theater Command, 83 Wen Hua Road, Shenyang, 110016, Liaoning, China.

BMC Nephrology
|January 23, 2022
PubMed

Insights

Cardiac valve calcification (CVC) significantly increases mortality in maintenance hemodialysis (MHD) patients. Echocardiography can help stratify risk for these patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Research

Background:

  • Cardiac valve calcification (CVC) is prevalent in end-stage renal disease (ESRD) patients.
  • The impact of CVC on mortality in maintenance hemodialysis (MHD) patients requires further investigation.

Purpose of the Study:

  • To investigate the association between CVC and all-cause and cardiovascular (CV) mortality in MHD patients.
  • To assess the prognostic value of mitral valve calcification (MVC) and aortic valve calcification (AVC) in this population.

Main Methods:

  • Retrospective cohort study of 434 MHD patients with echocardiography data.
  • Comparison of baseline characteristics between CVC and non-CVC groups.
  • Kaplan-Meier and multivariate Cox regression analyses for mortality outcomes.

Main Results:

  • 27.2% had MVC, 31.8% had AVC.
  • Patients with CVC exhibited significantly higher all-cause and CV mortality rates (log-rank P < 0.001).
  • MVC and AVC were independent predictors of all-cause (HR: 1.517, P=0.010; HR: 1.433, P=0.028) and CV mortality (HR: 2.340, P<0.001; HR: 2.410, P<0.001).

Conclusions:

  • Mitral and aortic valve calcification significantly elevate mortality risks in MHD patients.
  • Echocardiography serves as a valuable tool for risk stratification in MHD patients with CVC.
Abstract

Keywords:
Cardiac valve calcificationHemodialysisMortality

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