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Impact of Fetuin-A, Lp(a), matrix gla protein and macrophage density on calcific aortic valve disease: a clinical
Cong Liu1,2,3, Haifeng Liu4, Ting Xie5
1Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.
Insights
Calcific aortic valve disease (CAVD) is increasing in older adults. Fetuin-A, MGP, and Lp(a) are linked to CAVD occurrence and may predict its diagnosis.
Area of Science:
- Cardiology
- Biochemistry
- Geriatrics
Background:
- Calcific aortic valve disease (CAVD) presents a growing health challenge, particularly in aging populations, often with subtle initial symptoms.
- Understanding the clinical factors associated with CAVD is crucial for early detection and management.
Purpose of the Study:
- To investigate the association between various clinical characteristics and the incidence of calcific aortic valve disease (CAVD).
- To identify potential biomarkers for the diagnosis of CAVD.
Main Methods:
- A retrospective study involving patients diagnosed with CAVD and healthy controls between January 2019 and February 2021.
- Collection and comparison of clinical, ultrasonic, serological, and histological data.
- Logistic regression and Pearson correlation analyses were employed to determine associations.
Main Results:
- Elevated levels of Fetuin-A and Lp(a) and reduced levels of MGP were significantly associated with CAVD occurrence.
- Fetuin-A and Lp(a) showed a positive correlation with disease progression, while MGP and macrophage density exhibited a negative correlation.
- Several clinical and serological indicators, including blood pressure and lipid profiles, differed significantly across disease severity groups.
Conclusions:
- Fetuin-A, MGP, and Lp(a) are independently associated with the occurrence of CAVD.
- These factors demonstrate potential as predictive biomarkers for the diagnosis of calcific aortic valve disease.
Background:
Calcific aortic valve disease (CAVD) has a substantial and increasing burden in the ageing population with occult onset.Present study aimed to assess association of clinical characteristics of these patients and occurrence of CAVD.
Methods:
Patients diagnosed with CAVD and those receiving healthy medical examination in our hospital from January 2019 to February 2021 were enrolled in this retrospective study. Clinical characteristics, ultrasonic indicators, serological indicators and histology of CAVD were collected and compared among different groups. Logistic regression and Pearson correlation analysis was used to explore relationship between these indexes and occurrence of CAVD.
Results:
DBP, SBP, LVESD, LVEDD, IVS, PW, AV Vmax, TC, TG, LDL-C, Fetuin-A, Lp(a) in severe group were higher than mild, moderate and control groups (P<0.05), while those indexes of patients in moderate group were higher than that in mild and controlled groups (P<0.05). Besides, theses indexes of patients in mild group were also higher than that of controlled one (P<0.05). However, LVEF, HDL-C and MGP of patients in severe group was the lowest (P<0.05), while those in moderate group were lower than mild and controlled groups. Moreover, these indexes in mild group were also lower than control group (P<0.05). In Logistic regression analysis, MGP, Fetuin-A and Lp(a) were all independently associated with occurrence of CAVD (P<0.05). In Pearson correlation analysis, Fetuin-A and Lp(a) were positively correlated with progression of the disease, while MGP and macrophage density were negatively correlated with it.
Conclusions:
Fetuin-A, MPG and Lp(a) were independently associated with the occurrence of CAVD, and they might be potential predictors for diagnosis of this disease.
