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Noninvasive transdermal delivery of mesoporous silica nanoparticles using deep eutectic solvent
Zhiyuan Zhao1, Mingjian Li1, Luyao Zheng2
1School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
Summary
This study introduces a novel, noninvasive method for transdermal delivery of mesoporous silica nanoparticles (MSNs) using a deep eutectic solvent (DES). This approach enhances skin penetration, enabling nanoparticles to reach the bloodstream via topical application.
Area of Science:
- Materials Science
- Nanotechnology
- Dermatology
Background:
- Transdermal delivery of solid nanoparticles is challenging, with microneedles and injections being primary methods.
- Existing methods for nanoparticle skin penetration are invasive or limited in efficacy.
Purpose of the Study:
- To develop a noninvasive strategy for enhanced transdermal delivery of mesoporous silica nanoparticles (MSNs).
- To investigate the potential of a novel deep eutectic solvent (DES) system for nanoparticle skin permeation.
Main Methods:
- Surface modification of MSNs with citric acid (CA) and reaction with Lysine (Lys) to form a DES-MSNs system.
- Utilizing amino acid-citric acid (AA-CA) DES for nanoparticle delivery.
- Intradermal and transdermal penetration assays to evaluate skin permeation efficacy.
Main Results:
- The AA-CA DES demonstrated significant enhancement of MSN skin penetration ability via a "Drag" effect.
- This is the first study to achieve topical transdermal delivery of nanoparticles into the blood circulation.
- Successful transdermal delivery of MSNs into the bloodstream was achieved.
Conclusions:
- A novel, noninvasive strategy for transdermal nanoparticle delivery using DES has been established.
- The AA-CA DES system facilitates efficient MSN penetration across the entire skin layer.
- This work offers a new avenue for controlled and sustained nanoparticle drug delivery systems.
