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Updated: Oct 5, 2025
Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Gastrointestinal pathologic findings of teriflunomide associated diarrhea
Jessica H Fan1, Franz Fogt2, Joseph R Berger1
1Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, United States.
Background:
Diarrhea is generally a benign and self-limited adverse effect of teriflunomide. Small intestinal pathology has yet to be described with teriflunomide associated diarrhea.
Objective:
To report small intestinal pathology in teriflunomide associated diarrhea.
Methods:
Small intestinal and colonic biopsies were obtained from a patient with teriflunomide associated diarrhea.
Results:
Small intestinal biopsy demonstrated blunting of villi, increased intraepithelial lymphocytes and expansion of lamina propria. Gliadin and t-transglutaminase antibodies were negative. Diarrhea resolved following elimination of teriflunomide with cholestyramine.
Conclusion:
This is the first reported case of small intestinal inflammation similar to celiac disease in teriflunomide associated diarrhea.
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