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Related Concept Videos

Glial Cells01:04

Glial Cells

90.1K
Overview
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Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

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Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Related Experiment Video

Updated: Oct 5, 2025

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
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Glial Cells Response in Stroke.

Poonam Jadhav1, Mayuri Karande1, Abhishek Sarkar1

  • 1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, 382355, India.

Cellular and Molecular Neurobiology
|January 23, 2022
PubMed
Summary

This review explores glial cells

Keywords:
Blood–brain barrierGlial cellsIschemic strokeNeuroprotectionTherapeutic target

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Last Updated: Oct 5, 2025

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Stroke is a leading cause of death with limited treatment options.
  • Current therapies like recombinant tissue plasminogen activator and mechanical thrombectomy have narrow therapeutic windows and risks.
  • Identifying factors exacerbating ischemic outcomes is crucial for developing new stroke treatments.

Purpose of the Study:

  • To review the multifaceted roles of glial cells in ischemic stroke pathology.
  • To highlight glial cells as potential therapeutic targets for neuroprotection.
  • To summarize emerging therapeutic strategies focused on glial cell modulation.

Main Methods:

  • Literature review of glial cell function in ischemic brain injury.
  • Analysis of glial cell involvement in inflammatory responses post-stroke.
  • Examination of current and developing therapeutic interventions targeting glial cells.

Main Results:

  • Glial cells (microglia, astrocytes, oligodendrocytes) play a critical dual role in stroke's inflammatory process.
  • Understanding glial cell mechanisms can identify new therapeutic targets.
  • Targeting glial cells offers potential for neuroprotective agents in stroke treatment.

Conclusions:

  • Glial cells are key players in stroke pathology and prognosis.
  • Modulating glial cell activity presents a promising avenue for novel stroke therapies.
  • Developing neuroprotective agents targeting glial cells could improve ischemic stroke treatment outcomes.