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Updated: Aug 6, 2026
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
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[Methicillin-resistant Staphylococcus epidermidis infectious keratitis: Clinical and microbiological profile]
L Vidal Oliver, P Bayo Calduch, L Forqué Rodríguez
1Javier Colomina Rodriguez. Servicio de Microbiología, Hospital Clínico Universitario de Valencia. Spain. jcolominarodri@yahoo.es.
Summary
Methicillin-resistant Staphylococcus epidermidis (MRSE) is a frequent cause of infectious keratitis, exhibiting significant multidrug resistance. Clinically, MRSE keratitis presents similarly to methicillin-susceptible S. epidermidis (MSSE) keratitis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Staphylococcus epidermidis (SE) is a prevalent cause of bacterial keratitis in specific regions.
- Methicillin resistance in SE (MRSE) confers cross-resistance to beta-lactams and other antibiotic classes.
- Understanding the clinical and microbiological profiles of SE keratitis is crucial for effective treatment.
Purpose of the Study:
- To analyze clinical and microbiological variables in patients with infectious keratitis caused by Staphylococcus epidermidis.
- To compare the characteristics of methicillin-resistant SE (MRSE) and methicillin-susceptible SE (MSSE) keratitis.
Main Methods:
- Retrospective analysis of medical records from 43 patients with microbiologically confirmed SE keratitis (October 2017 - October 2020).
- Evaluation of clinical factors (risk factors, lesion size, treatment, outcomes) and microbiological data (antibiotic susceptibility).
- Comparison between MRSE and MSSE infection groups.
Main Results:
- MRSE accounted for 37.2% of SE infectious keratitis cases.
- All SE isolates remained susceptible to vancomycin and linezolid.
- MRSE isolates showed high resistance rates to tetracyclines (50%) and ciprofloxacin (56%), compared to MSSE (11% and 7%, respectively).
- No statistically significant differences in clinical characteristics were observed between MRSE and MSSE groups.
Conclusions:
- Methicillin-resistant Staphylococcus epidermidis is a common pathogen in infectious keratitis with substantial multidrug resistance.
- Clinically, MRSE keratitis is indistinguishable from MSSE keratitis.
- Further research is warranted to validate these findings and guide therapeutic strategies.
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