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Intrinsic Capacity Defined Using Four Domains and Mortality Risk: A 5-Year Follow-Up of the SarcoPhAge Cohort
M Locquet1, D Sanchez-Rodriguez, O Bruyère
1Médéa Locquet, M.Sc., PhD, CHU de Liège, Avenue Hippocrate 13, 4000 Liège, Belgium, 003243662519, medea.locquet@gmail.com.
The Journal of Nutrition, Health & Aging
|January 24, 2022
Summary
Intrinsic capacity (IC), encompassing mobility and psychological well-being, predicts mortality risk in older adults. Deterioration in these IC domains over time significantly increases the risk of death.
Area of Science:
- Gerontology
- Public Health
- Biomedical Science
Background:
- Healthy aging is a complex concept.
- Intrinsic capacity (IC) offers a novel framework for assessing healthy aging.
- Understanding factors influencing healthy aging is crucial for public health initiatives.
Purpose of the Study:
- To evaluate the predictive ability of intrinsic capacity (IC) for mortality in older adults.
- To determine if changes in IC over one and two years predict mortality.
- To explore the association between specific IC domains and mortality risk.
Main Methods:
- Prospective cohort study of 481 community-dwelling adults aged 65 years and older.
- Intrinsic capacity (IC) assessed across cognition, nutrition, mobility, and psychological domains.
- Cox models used to analyze the relationship between IC and mortality, including dynamic changes.
Main Results:
- Satisfactory mobility and psychological domains were significantly associated with reduced mortality risk.
- A one standard deviation increase in composite IC score decreased mortality risk by 49%.
- Deterioration in mobility and psychological domains over 1-2 years increased mortality risk 2.74 to 4.18-fold.
Conclusions:
- Intrinsic capacity (IC) is a relevant construct for assessing health and well-being in older adults.
- Specific domains of IC, particularly mobility and psychological health, are key predictors of mortality.
- The findings support the integration of IC assessment into clinical practice for geriatric care.
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