The significance of the SDF-1/CXCR4 signaling pathway in the normal development
Farzad Sadri1, Zohreh Rezaei2,3, Mohammad Fereidouni4,5
1Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Abstract:
Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and physiological mechanisms, including embryogenesis, wound healing, angiogenesis, tumor growth, and proliferation. Therefore, the current review aimed to summarize the related studies that addressed the molecular signature of the SDF-1/CXCR4 pathway and to explain how this axis is involved in normal events.
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