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Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
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When analyzing bending in symmetric members, it's crucial to understand how stresses distribute when subjected to bending moments. This stress distribution is effectively described by applying fundamental mechanics and material science principles, particularly Hooke's Law for elastic materials.
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Fascia, a thin layer of fibrous connective tissue, is distributed throughout the body. It demarcates and forms a supportive covering over skeletal muscles, bones, blood vessels, and organs. There are three main types of facia— superficial fascia, deep fascia, and subserous fascia. These are all present at different depths in the body. Fascia reduces the friction and permits muscles, joints, and organs to easily slide against each other, facilitating movement of the body and preventing...
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Updated: Oct 5, 2025

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
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Painful flexural plaques.

Áine Kelly1, Nilu Wijesuriya2, Mickey Koh3

  • 1Dermatology, St George's University Hospital, London, UK.

Clinical and Experimental Dermatology
|January 24, 2022
PubMed
Summary
This summary is machine-generated.

A man had persistent, painful skin plaques in his groin and armpits for six years. This case highlights a rare dermatological condition causing significant discomfort and scarring.

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Area of Science:

  • Dermatology
  • Clinical Case Study

Background:

  • Chronic skin conditions can significantly impact patient quality of life.
  • Understanding rare dermatological presentations is crucial for accurate diagnosis.

Observation:

  • A 30-year-old male presented with a six-year history of eroded, orange-red plaques.
  • Lesions were located in the bilateral axilla, groin, and perianal regions.
  • Symptoms included pain, scarring, and limited shoulder extension.

Findings:

  • The case describes a unique presentation of chronic skin lesions.
  • The morphology and distribution suggest a specific, albeit unnamed in the abstract, dermatosis.
  • Functional impairment (limited shoulder extension) indicates disease severity.

Implications:

  • This case underscores the importance of recognizing and managing chronic, debilitating skin diseases.
  • Further investigation may be needed to determine the exact etiology and optimal treatment.
  • Such presentations can lead to significant morbidity if not addressed promptly.