Development of the gonadotropin-releasing hormone system
Anne H Duittoz1, Paolo E Forni2,3, Paolo Giacobini4
1CNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
Journal of Neuroendocrinology
|January 24, 2022
Summary
This review explores the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system. It covers gene regulation, prenatal development in humans and rodents, and cell migration signaling.
Area of Science:
- Neuroendocrinology
- Developmental Biology
Background:
- The neuroendocrine gonadotropin-releasing hormone (GnRH) system regulates reproduction.
- Understanding its development is crucial for reproductive health.
Purpose of the Study:
- To review the current knowledge on GnRH system development.
- To highlight key open questions in the field.
Main Methods:
- Literature review of existing research on GnRH system development.
- Synthesis of findings on gene regulation, prenatal development, and cell migration.
Main Results:
- The Gnrh1 gene's transcriptional regulation is complex and not fully understood.
- Prenatal development of the GnRH system shows conserved and divergent features in rodents and humans.
- Paracrine and synaptic communication are critical for GnRH cell migration.
Conclusions:
- Further research is needed to elucidate GnRH gene regulation.
- Comparative studies in rodents and humans can reveal developmental insights.
- Investigating cell-cell communication is key to understanding GnRH system formation.
Keywords:
GnRHdevelopmentguidance cuesmigratory pathwayolfactory ensheathing cellsolfactory placodesynaptic and paracrine signalsterminal nervetranscription factorsMore Related Videos
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