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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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COVID-19 in CKD Patients: Report from India

Nikita Pawar1, Vaibhav Tiwari1, Anurag Gupta1

  • 1Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India.

Indian Journal of Nephrology
|January 24, 2022
PubMed

Insights

Hospitalized patients with chronic kidney disease (CKD) face a high mortality rate from COVID-19, especially those with severe disease or requiring renal replacement therapy.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Limited data exists on coronavirus disease-2019 (COVID-19) outcomes in non-dialysis-dependent chronic kidney disease (CKD) patients.
  • COVID-19 primarily presents as an acute respiratory illness, but its impact on CKD populations is not well-defined.

Purpose of the Study:

  • To investigate the clinical characteristics and outcomes of hospitalized CKD patients with COVID-19.
  • To identify factors associated with mortality in this vulnerable patient group.

Main Methods:

  • A single-center retrospective observational study.
  • Included consecutive non-dialysis CKD patients (eGFR <60 mL/min/1.73 m²) admitted with COVID-19 between April and July 2020.

Main Results:

  • Out of 30 patients, 50% had CKD stage 5, and the overall mortality rate was 53.3%.
  • 83.3% developed acute kidney injury on CKD, and 67% required renal replacement therapy (RRT), with poor prognosis for RRT patients.
  • High LDH, IL-6, and lymphopenia were associated with fatal outcomes; severe COVID-19 cases had an 11% survival rate.

Conclusions:

  • Hospitalized CKD patients exhibit a high mortality rate due to COVID-19.
  • Severity of COVID-19 and need for RRT significantly impact survival in CKD patients.
Abstract

Keywords:
AKICKDCoronavirusCovid19SARSCoV2

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